Table Of Content
As an anti-inflammatory agent, it’s possible that glutathione deficiency could exacerbate the microinflammation in AGA follicles — a process that drives the hair loss observed in AGA (7, 9). As such, we can’t expect vitamin B1 to actually improve Hashimoto’s thyroiditis or the hair loss that occurs as a result. Instead, vitamin B1 can only improve symptoms related to a vitamin B1 deficiency that may occur alongside the condition.
Why vitamin B1 might be bad for hair: the NADPH-DHT connection
Nicotinamide adenine dinucleotide phosphate (NADPH) oxidase is an enzyme complex that is responsible for the generation of a considerable amount of ROS [5]. This enzyme plays an essential role in isoproterenol (ISO)-mediated ROS production and myocardial cytotoxicity; consequently, its inhibition could represent a promising therapeutic target for the treatment of myocardial damage [6]. Acute myocardial infarction (AMI) remains the most common cause of morbidity and mortality worldwide. The present study was directed to investigate the beneficial effects of benfotiamine pre- and post-treatments in isoproterenol (ISO)-induced MI in rats.
How we reviewed this article:
Biotin (vitamin B7) is a micronutrient vital to energy production, nervous system health, and other bodily functions. Found in a plethora of foods and available as a supplement, biotin is most well-known for strengthening hair and nails and combatting alopecia. Taking a dose of benfotiamine a half hour after drinking alcohol has shown to prevent liver damage in mice.
What are the best treatments for alopecia?
Many people who undergo chemotherapy choose to proudly display their new look. Remember that if you’re going through a tough health situation, you have every right to be proud of how you’re fighting it. If you’ve recently begun taking a new medication and have noticed hair thinning or loss, talk to your doctor about switching to another medication. They may be able to choose a medicine that doesn’t cause the same side effect. Your doctor may also recommend that you stop taking the medication for a few months.
A portion of thiamine is further phosphorylated by thiamine pyrophosphokinase to ThDP (Fig. 3) [64]. However, when investigating the effect of benfotiamine and thiamine on Nrf2/ARE pathway, master regulator of cellular antioxidative response, Tapias et al. found that benfotiamine and its metabolites activate this pathway [21]. However, this is not true for thiamine, suggesting that antioxidative effects of benfotiamine are not exerted through thiamine, or that potentially there is another mechanism involved. The first lipophilic thiamine derivative was found in garlic and was named allithiamine for the Allium genus to which garlic belongs [57]. Afterwards, several lipophilic analogs were synthesized, including fursultiamine, sulbutiamine and benfotiamine. This work was mostly done in Japan in the 1950s and 1960s, because beriberi was a widespread health problem in Japan [58].
“Opt for hairstyles that minimize tension on the hair follicles, such as loose braids, buns or ponytails,” advises Gaboardi. “Avoid tight hairstyles and hair accessories that pull on the hair and handle your hair with care to minimise breakage and damage. If you notice symptoms of biotin deficiency, seek help from your healthcare provider. Your healthcare provider can diagnose a biotin deficiency by carefully analyzing your symptoms and lab work. Increasing biotin in your diet or via supplementation can be vital in correcting your deficiency.
Symptoms of Biotin Deficiency
The Reasons Why You Can Get a Vitamin B Rash, Hives or Flush - Livestrong
The Reasons Why You Can Get a Vitamin B Rash, Hives or Flush.
Posted: Sat, 26 Sep 2015 15:14:46 GMT [source]
Our group has demonstrated that benfotiamine suppresses oxidative stress and upregulates antioxidative system in activated BV-2 microglial cells [19]. Benfotiamine decreased production of NO, superoxide anion and MDA, and increased levels and activities of superoxide dismutase, catalase and glutathione. Thus, benfotiamine was shown to be effective in suppressing both inflammation and oxidative stress, two hallmarks of chronically activated microglia [19]. Similarly, benfotiamine suppressed ROS levels in LPS treated macrophages [14], as well as levels of protein-HNE adducts and lipid hydroperoxides [15]. Antioxidative effects of benfotiamine were also shown in three different kidney cell lines [12].
What’s the Health Link?
After two and a half weeks, some mice began to experience rapid weight loss, followed by abnormal hair shedding. After four weeks, the mice were confused and could barely walk – symptoms similar to those seen in humans with beri beri. We conducted a systematic review of manuscripts (original papers and reviews) by searching the Medline database on PubMed and Google (Google Scholar) and Scopus search engines from inception to December 2022. We used as search terms (thiamine and/or benfotiamine; thiamine deficiency) OR (thiamine/benfotiamine, inflammation) AND (thiamine/benfotiamine, nervous system) AND (thiamine/benfotiamine, oxidative stress). In conclusion, despite a marked improvement in thiamine status, long-term high-dose benfotiamine had no significant effect on peripheral nerve function or inflammatory markers in patients with type 1 diabetes. PKC activation mediates inflammatory response signals through NF-κB pathway (Kim et al. 2013).
Peripheral nerve function and levels of soluble inflammatory variables were assessed at baseline and at 24 months. Goette et al. described nine patients who developed TE after 2–5 months of starting a vigorous weight reduction program and losing 11.7–24 kg. It was thought that rigorous caloric restriction with subsequent inadequate energy supply of the hair matrix might be the cause for the precipitation of TE of the crash dieter [133]. In addition, a few case reports have been published relating TE with crash diet [134–136].
This process requires NADPH, which requires vitamin B1 (along with various other B vitamins) (6). Autoimmune conditions that affect the thyroid – like Graves’ disease and Hashimoto’s thyroiditis – can have a domino effect on hair growth which is, in part, controlled by thyroid hormones. When these hormones get too high (i.e., Graves’ disease) or too low (i.e., Hashimoto’s thyroiditis), it can cause telogen effluvium – a form of diffuse hair shedding. In humans and animals, thiamine deficiency has been shown to decrease myelin fiber density and consequently lead to myelin sheath damage with selective neuronal death and glutamate-related excitotoxicity [[40], [41], [42]].
In fact, if your body has a thiamine or benfotiamine deficiency, you may face serious health complications. These deficiencies have been linked to emotional disturbances, dangerous weight loss, impaired sensory perception, periods of irregular heart rate and much worse. Needless to say, 99.9% of us probably don’t need to be supplementing with vitamin B1 as a hair loss preventive. In fact, given vitamin B1’s relationship to NADPH production, and NADPH’s relationship to DHT, we could make a similar logic-leap argument that too much vitamin B1 may exacerbate hair loss. Yes, if we stretch our imagination, it’s possible that a vitamin B1 deficiency might decrease glutathione production, and that if enough of this occurs in balding hair follicle sites, this decrease might exacerbate inflammation in AGA.
Benfotiamine, which turns into thiamine once it’s inside your body, may build up to helpful levels more easily. These drugs are designed to destroy the fast-growing cancer cells in your body, but they also attack and destroy other cells that grow quickly, like the roots of your hair. So, while some people taking weight loss drugs have reported hair loss, that loss could be due to malnutrition. Weight loss medications like phentermine can cause hair loss, but the side effect isn’t often listed. This is because dieters who lose their hair are often also nutrient-deficient or may have underlying health conditions contributing to their hair loss. Medications that prevent seizures, like valproic acid (Depakote) and trimethadione (Tridione), can lead to hair loss in some people.
No comments:
Post a Comment